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AIM:To investigate the relationship between serumsoluble interleukin-2 receptor(sIL-2R)level and anti-HBcin patients with chronic hepatitis B virus(HBV)infection.METHODS:Sera from 100 patients with chronic HBVinfection and 30 healthy controls were included in thisstudy.The patients were divided into group A[HBsAg(+),HBeAg(+)and anti-HBc(+),n=50]and group B[HBsAg(+),HBeAg(+)and anti-HBc(-),n=50].sIL-2R levelswere determined using ELISA.HBV DNA and alanineaminotransferase(ALT)were also detected.RESULTS:Serum sIL-2R levels were significantly higherin patients with chronic HBV infection than in healthycontrols.Moreover,serum sIL-2R levels were significantlyhigher in patients with HBsAg(+),HBeAg(+)and anti-HBc(+)(976.56±213.51×10~3 U/L)than in patients withHBsAg(+),HBeAg(+)and anti-HBc(-)(393.41±189.54×10~3 U/L,P<0.01).A significant relationship was foundbetween serum sIL-2R and ALT levels(P<0.01)inpatients with chronic HBV infection,but there was nocorrelation between sIL-2R and HBV DNA levels.Theanti-HBc status was significantly related to the age ofpatients(P<0.01).CONCLUSION:The high sIL-2R level is related topositive anti-HBc in chronic hepatitis B patients.Positiveanti-HBc may be related to T-lymphocyte activation andnegative anti-HBc may imply immune tolerance in thesepatients.
AIM: To investigate the relationship between serum soluble interleukin-2 receptor (sIL-2R) level and anti-HBcin patients with chronic hepatitis B virus (HBV) infection. METHODS: Sera from 100 patients with chronic HBV infection and 30 healthy controls were included in this study The patients were divided into groups A [HBsAg (+), HBeAg (+) and anti-HBc (+), n = 50] and group B [HBsAg (+), HBeAg (+) and anti-HBc Serum sIL-2R levels were significantly higher in patients with chronic HBV infection than in healthy controls. Moreover, serum sIL-2R The levels of significantlyhigher in patients with HBsAg (+), HBeAg (+) and anti-HBc (+) (976.56 ± 213.51 × 10 ~ 3 U / L) than in patients with HBsAg (-) (393.41 ± 189.54 × 10 ~ 3 U / L, P <0.01) .A significant relationship was foundbetween serum sIL-2R and ALT levels (P <0.01) inpatients with chronic HBV infection, but there was nocorrelation between sIL- 2R and HBV DN A levels.Theanti-HBc status was significantly related to the age ofpatients (P <0.01) .CONCLUSION: The high sIL-2R level is related topositive anti-HBc in chronic hepatitis B patients. Positive anti-HBc may be related to T-lymphocyte activation andnegative anti-HBc may imply immune tolerance in thesepatients.