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目的探讨胃癌组织中成纤维细胞激活蛋白(FAP)的表达与临床病理特征和预后的关系。方法选取2009年4月至2011年3月间江苏省中国人民解放军第82医院行手术治疗的121例胃癌患者的胃癌组织标本为研究对象,采用免疫组化染色检测癌变组织及距离癌变组织超过5cm处正常组织中FAP的表达情况,分析其与临床病理特征的关系。对患者进行5年随访,分析FAP表达与患者预后生存的关系。结果 121例胃癌病理组织中FAP表达阳性者为109例(90.1%),FAP阳性表达细胞数平均为(32.99±13.24)个,FAP在癌旁正常组织中的表达均为阴性。胃癌组织中FAP表达与患者肿块直径、分化程度、TNM分期和淋巴转移有关,差异均有统计学意义(均P<0.05),与患者年龄、性别和是否吸烟无关。胃癌组织FAP高表达患者的平均生存时间及95%CI为35.29(27.82,42.77)个月,而低表达患者平均生存时间及95%CI为44.15(38.84,49.46)个月,两者比较,差异有统计学意义(P<0.05)。结论胃癌组织中FAP呈高表达,与胃癌的生长、进展和预后有关。
Objective To investigate the relationship between the expression of fibroblast activating protein (FAP) and clinicopathological characteristics and prognosis in gastric cancer. Methods The gastric cancer tissue samples from 121 patients with gastric cancer underwent surgery from April 2009 to March 2011 in the 82nd Hospital of Jiangsu Province were enrolled. The specimens of cancerous tissues and cancerous tissues more than 5cm Department of normal tissue FAP expression, analysis of its relationship with clinicopathological features. The patients were followed up for 5 years to analyze the relationship between FAP expression and prognosis of patients. Results The positive expression of FAP in 121 gastric cancer tissues was 109 (90.1%), the average number of FAP positive cells was (32.99 ± 13.24), and the expression of FAP in adjacent normal tissues was negative. FAP expression in gastric cancer tissue was correlated with tumor diameter, differentiation, TNM stage and lymph node metastasis (all P <0.05), but not with age, sex and smoking status. The mean survival time and 95% CI of patients with high expression of FAP in gastric cancer tissues were 35.29 (27.82,42.77) months, while the average survival time and 95% CI of low expression patients were 44.15 (38.84,49.46) months. There was significant difference between the two groups There was statistical significance (P <0.05). Conclusion The expression of FAP in gastric cancer is highly correlated with the growth, progression and prognosis of gastric cancer.