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目的观察金水宝胶囊联合阿拓莫兰(还原型谷胱甘肽)、熊去氧胆酸治疗非酒精性脂肪性肝病(NAFLD)的临床疗效。方法选取符合NAFLD诊断标准的94例患者作为观察对象,随机分为两组,对照组46例在调整饮食结构,适量有氧运动等基础上给予阿拓莫兰、熊去氧胆酸治疗,治疗组48例在对照组的基础上,加服金水宝胶囊。观察两组症状、体征的变化,血清丙氨酸氨基转移酶(ALT)、甘油三酯(TG)、r-谷氨酰转移酶(r-GT)及肝脏B超等变化。结果治疗组显效率、总有效率均高于对照组(P<0.05);ALT、TG、r-TG较治疗前有明显好转,与对照组比较差异有统计学意义(P<0.05)。治疗组肝脏B超检查,结果均有不同程度的减轻或复常。结论金水宝胶囊联合阿拓莫兰、熊去氧胆酸治疗NAFLD效果良好。
Objective To observe the clinical efficacy of Jinshuibao capsule combined with exopamine (reduced glutathione) and ursodeoxycholic acid in the treatment of non-alcoholic fatty liver disease (NAFLD). Methods Ninety-four patients with NAFLD diagnostic criteria were selected as observation objects and randomly divided into two groups. The control group received adjuvant treatment with atomolanol and ursodeoxycholic acid on the basis of adjusting the diet and appropriate aerobic exercise. Group of 48 cases in the control group, based on the addition of gold Shui Bao capsule. The changes of symptoms, signs, serum ALT, TG, r-GT and liver B-ultrasound were observed. Results The effective rate and total effective rate in the treatment group were significantly higher than those in the control group (P <0.05). The levels of ALT, TG and r-TG in the treatment group were significantly improved compared with those in the control group (P <0.05). Treatment group liver B-ultrasound, the results have varying degrees of reduction or normalization. Conclusions Jinshuibao capsule combined with epinephrine and ursodeoxycholic acid is effective in treating NAFLD.