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目的:探讨趋化因子基质细胞衍生因子-1(Stromal cell-derived factor-1α,SDF-1)在非小细胞肺癌组织和癌旁组织中的表达情况,并研究其与微血管密度(MVD)在血管生成和临床病理特征方面的关系。方法:采用免疫组化法检测42例NSCLC患者癌组织和30例癌旁组织中基质细胞衍生因子1及微血管密度的表达情况。结果:在对照组中,SDF-1的表达率为10%;在NSCLC中,阳性表达率为62.3%,P<0.05,有统计学意义。且有淋巴结转移、TNM分期越高,则SDF-1表达率越高,与性别、病理类型和分化程度无相关性;MVD在NSCLC中计数为36.74±11.708,与TNM分期,分化程度及有无淋巴结转移有相关性,与性别、病理类型无相关性。癌组织中,SDF与MVD正相关。结论:在NSCLC癌组织中,SDF-1和MVD呈现高表达,说明SDF-1可能通过促进肿瘤的血管生成而参与肺癌的浸润转移,是肺癌血管形成的正性因子,为临床有效评估肺癌浸润转移程度及预后提供依据。
Objective: To investigate the expression of chemokine Stromal cell-derived factor-1α (SDF-1) in non-small cell lung cancer tissues and paracancerous tissues, and to investigate its relationship with microvessel density (MVD) Angiogenesis and clinicopathological characteristics of the relationship. Methods: Immunohistochemistry was used to detect the expression of stromal cell derived factor-1 and microvessel density in 42 NSCLC patients and 30 para-cancerous tissues. Results: In the control group, the expression rate of SDF-1 was 10%; in NSCLC, the positive expression rate was 62.3%, P <0.05, with statistical significance. There was lymph node metastasis. The higher the TNM stage, the higher the expression rate of SDF-1 was, and there was no correlation with sex, pathological type and differentiation degree. The MVD in NSCLC was 36.74 ± 11.708, which was correlated with TNM staging, differentiation and presence There was a correlation between lymph node metastasis and sex, pathological type. In cancer, SDF was positively correlated with MVD. Conclusion: SDF-1 and MVD are highly expressed in NSCLC tissues, indicating that SDF-1 may participate in invasion and metastasis of lung cancer by promoting tumor angiogenesis and is a positive factor of angiogenesis in lung cancer. It is a clinically effective measure for lung cancer invasion The degree of metastasis and prognosis provide the basis.