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[目的 ]观察复方蒿甲醚及其组分之一苯芴醇两种剂型对恶性疟的疗效和安全性。 [方法 ]共收治 15 0例恶性疟患者 ,采用双盲 (复方蒿甲醚片组和苯芴醇片组 )、随机、对比方法 ,其中复方蒿甲醚组 (A) 5 1例、苯芴醇片剂组 (B) 5 0例、苯芴醇胶丸组 (C) 4 9例。病人住院后观察 2 8d。 [结果 ]A、B、C3组的平均退热时数分别为 (17.1±8.6 ) h、(34.0± 2 3.2 )和 (2 9.4± 2 4.9) h;平均原虫转阴时间分别为 (2 9.7± 8.9) h、(5 1.6± 14.1) h和 (5 4.7± 17.4) h;3组患者均达到临床治愈 ;观察期间无明显不良反应 ,化验检查亦无明显改变。 [结论 ]复方蒿甲醚和苯芴醇两种剂型对恶性疟均有良好的治疗作用 ,复方蒿甲醚在杀虫速度和控制症状方面明显优于苯芴醇单药
[Objective] To observe the curative effect and safety of two kinds of formulations of compound artemether and one of its components lumefantrine on falciparum malaria. [Methods] A total of 150 cases of falciparum malaria were treated with double-blind (compound artemether tablets and lumefluramine tablets group), randomized, comparative methods, including compound artemether group (A) 51 cases of benzene fluorene 50 tablets in the alcohol tablet group (B) and 49 cases in the lumefantrine capsule group (C). The patient was observed 2 8 days after hospitalization. [Results] The average number of antipyretic hours in groups A, B and C3 were (17.1 ± 8.6) h, (34.0 ± 2 and 3.2) and (2 9.4 ± 2 4.9) h, respectively; ± 8.9) h, (5.16 ± 14.1) h and (4.7 ± 17.4) h, respectively. All three groups achieved clinical cure. No adverse reactions were observed during the observation period and no significant changes were found in laboratory tests. [Conclusion] Both the two formulations of compound artemether and lumefantrine have a good therapeutic effect on falciparum malaria, and the artemether compound is superior to lumeflumetol monotherapy in terms of insecticidal speed and symptom control