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目的:探讨survivin表达情况与食管鳞癌原发灶的放化疗反应的关系.方法:用免疫组化法检测112例食管鳞癌中survivin的表达情况,回顾性分析胞质和胞核的survivin表达与放化疗近期疗效及放化疗后降期情况的关系.结果:survivin的表达可见于肿瘤细胞的胞质或/和胞核内,其中胞核表达率为67.8%,胞质表达率为65.2%;胞质survivin表达与近期疗效无明显关系,而胞核survivin阴性者放化疗的中期有效率明显高于阳性者(80.6%vs46.1%,P=0.026).术前放化疗组中,核survivin阳性者与阴性者放化疗后降期的比例分别为7/17和4/4.结论:检测核survivin的表达情况可能作为预测食管鳞癌对放化疗疗效的有效参考指标.
Objective: To investigate the relationship between survivin expression and chemoradiotherapy response in primary esophageal squamous cell carcinoma.Methods: The expression of survivin in 112 cases of esophageal squamous cell carcinoma was detected by immunohistochemistry, and the expression of survivin in cytoplasm and nucleus was analyzed retrospectively And the relationship between the curative effect of chemotherapy and chemotherapy and the decline after radiotherapy and chemotherapy.Results: The expression of survivin was found in the cytoplasm and / or nucleus of the tumor cells, with a nuclear expression rate of 67.8% and a cytoplasmic expression rate of 65.2% ; The expression of cytoplasm survivin had no significant relationship with the short-term curative effect, while the mid-term radiotherapy and chemotherapy of nuclear survivin negative rate was significantly higher than the positive rate (80.6% vs46.1%, P = 0.026) The ratio of survivin positive and negative patients after radiotherapy and chemotherapy was 7/17 and 4/4, respectively.Conclusion: Detecting the expression of nuclear survivin may be a useful reference index for predicting the efficacy of radiotherapy and chemotherapy in esophageal squamous cell carcinoma.