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环孢素(CsA)是目前广泛用于器官移植中预防排斥反应最有效的免疫抑制剂,由于它的肝肾毒性较大以及具有药代动力学个体差异,因此在临床用药中进行CsA血药浓度监测非常必要。近年来关于CsA的药理与临床研究日益广泛深入,本文综述国内在CsA临床药理方面的研究进展。
CsA is currently the most widely used immunosuppressive agent in the prevention of rejection in organ transplantation. Due to its large hepatorenal toxicity and its individual differences in pharmacokinetics, CsA is used clinically Concentration monitoring is necessary. In recent years, the pharmacology and clinical research on CsA have been more and more extensive. This review summarizes the research progress in the clinical pharmacology of CsA in China.