LTP相关论文
本文应用免疫荧光、免疫沉淀、海马脑片场电位记录等技术研究了细胞周期蛋白cyclinD1/CDK4在不同发育期小鼠海马CA1区突触可塑性中......
背景衰老是神经退行性疾病的主要危险因素,存在学习记忆减退与突触可塑性（long term potentiation,LTP）受损。LTP是一种突触可塑性的......
背景蛋白质棕榈酰化修饰作为一种动态可逆的蛋白质翻译后修饰方式,广泛存在于中枢神经系统中,对神经网络活动和突触信号传递过程起......
Rho-associated kinases (ROCKs) are serinethreonine protein kinases that act downstream of small Rho GTPases to regulate ......
Objective: It was reported that melamine was deliberately added to infant formula in order to increase protein content.R......
DYT1 early-onset generalized torsion dystonia is an inherited movement disorder associated with mutations in DYT1 that c......
Agonists of sigma1-receptor,donepezil and PRE-084,rescue hippocampal long-term potentiation impaired
Donepezil is a potent acetylcholinesterase inhibitor used for the treatment of Alzheimers disease(AD)....
The effects of Colivelin on spatial memory and hippocampal long term potentiation in APP/PS1 transge
Objective: Alzheimers disease(AD)is the most common cause of dementia....
Amyloid plaques and tau tangles are common pathological hallmarks for Alzheimers disease(AD); however,reducing Aβ produ......
Derepression of tPA expression by knocking out NRSF enhances mature BDNF and upregulates hippocampal
Neuronal restrictive silencing factor (NRSF) is an epigenetic repressor with important role in regulating neurogenesis a......
Acute effects of 17β-estradiol on excitatory synaptic transmission and long-term potentiation in rat
Discussions about how estrogen modulates pain sensitivity have largely focused on genomic actions via nuclear receptors,......
Rapid effect of estrogen on glutamate related synaptic transmission and plasticity,in the anterior c
Classically, estrogen has multiple actions in the brain via genomic mechanisms which generally take several hours.The pr......
Serotonin (5-HT) deficiency is associated with cognitive deficits and psychiatric disorders,particularly anxiety and dep......
A lot of studies have demonstrated that NMDAR play an important role in regulating neuronal communication and synaptic f......
As the entry point of information into the hippocampus,the hippocampal dentate gyrus(DG)encodes and processes new inform......
Xanthotoxol ameliorates the ischemia/reperfusion-induced impairment of long-term potentiation induct
Aim: Cerebral ischemia can impair the induction of activity-dependent longterm potentiation (LTP) in the hippocampus.Her......
Chronic morphine treatment impaired hippocampal long-term potentiation and spatial memory via accumu
Chronic exposure to opiates impairs hippocampal long-term potentiation (LTP) and spatial memory, but the underlying mech......
Involvement of dopamine Dl-like receptor in activity-induced long-term potentiation of GABAergic syn
Activity-dependent long-term changes in synaptic efficacy are thought to be important in learning and memory formation.N......
N-methyl-D-asp.artate receptor(NMDA receptors) play a critical role in learning and memory.NR2A and NR2B subunits are pr......
Inhibition of NF-κB-dependent CX3CL1 upregulation attenuated the central sensitization and acute pai
Background:Acute and chronic painful peripheral neuropathy following the oxaliplatin treatment is the principle dose lim......
IGFBP2 is a pleiotrophic polypeptide that synthesized in the brain but still largely unknown its functions at neonatal b......
Melatonin prevents against the neurotoxicity of amyloid β protein in long-term potentation and neuro
Melatonin, an indole hormone secreted by the pineal gland, has been reported to have strong neuropeotective effects.Howe......
Acute administration of the low-dose Dehydroepiandrosterone-sulfate induces the mGluR5-denpendent lo
We have reported that acute administration of Dehydroepiandrosterone-sulfate(DHEAS) for 10 min induced a short-term pote......
14-3-3 proteins are implicated in the regulation of synaptic functions based on a Drosophila mutant model and mammalian ......
会议
目的：比较开心散和去远志开心散对APP/PS1 转基因小鼠海马在体突触长时程增强(long-term potentiation,LTP)、海马CA1 区、大脑皮层......
In reward-based learning,synaptic modifications depend on a brief stimulus and a temporally delayed reward,which poses t......
Role of D1 and D2 signaling in regulating functional and structural Synaptic Plasticity in the Motor
In Parkinson disease(PD),the main pathological change is dopaminergic neurons death in SNc.Patients with PD have deficit......
Given the NMDA receptor(NMDAR)plays a central role in various brain functions,the trafficking of NMDAR in response to sy......
Aim: To observe the effects of Baclofen on synaptic plasticity in rats with chronic cerebral hypoperfusion.Methods: Chro......
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Inhibition of LTP by β-amyloid is prevented by activation of β2 adrenoceotors and stimulation of cAM
The present study investigated the role of β-adrenoceptors and the downstream cAMP/PKA signaling pathway on the A β in......
GABAB receptor activation confers frequency-dependent long-term potentiation of developing hippocamp
Activity-induced long-term synaptic modification depends on the frequency of synaptic activation,a property extensively ......
5-HT3A receptors deficiency leads to impairment of hippocampal longterm synaptic plasticity and lear
The 5-hydroxytryptamine type-3A receptor (5-HT3AR) as the only ligand-gated ion channel in serotonin receptor family is ......
The aim of present study is to observe the effect of ginsenoside Rgls metabolites (primary metabolit ginsenoside Rhl and......
The adaptive mechanisms of homo-and heterosynaptic plasticity play an important role in learning and memory.In order to ......
Delta subunit-containing GABAA receptor disinhibits the lateral amygdala and facilitates fear expres
Maintaining GABAergic inhibition in the amygdala within a physiological range is critical for the appropriate expression......
基于突触可塑性所涉及的基因表达过程与神经元动作电位的产生，我们建立了一个针对于LTP 的协作性、输入特异性和联合性的计算模型。......
Long term potentiation (LTP) is the key cellular mechanism for physiological learning and pathological chronic pain.In c......
Clonidine improves cognitive deficits by regulating synaptic strength in chronic cerebral hypoperfus
Permanent bilateral occlusion of the common carotid arteries in rats is an established experimental model to investigate......
女性是被动吸烟的主要人群,在中国,怀孕妇女被动吸烟率高达70﹪以上,孕期处于烟雾环境对幼儿智力发育的影响及抗氧化剂是否可以通过......
Chronic intermittent hypoxia-induced impairment in hippocampal synaptic plasticity and memory defici
Obstructive sleep apnea (OSA) is a common sleep and breathing disorder resulting in intermittent hypoxia (IH), and can c......
The functional maturation of visual cortex is sculpted by visual experience.To examine whether novel visual experien......
The mechanisms underlying long-term potentiation of C-fiber evoked field potentials in spinal dorsal
LTP of C-fiber evoked field potentials in spinal dorsal horn is first reported in 1995.Since then，thepathological signifi......
Alzheimers disease(AD)is the most common form of progressive neuro degenerative disease characterized by neuroinflam......
突触可塑性是指突触在神经元持续活动影响下发生的特异性数目、结构和功能的变化,它是学习记忆形成的基础,在神经功能中发挥重要的......
