cdk5相关论文
植物病害问题严重影响着农业自然资源的利用,目前人们主要是采用化学农药进行植物病原菌的防治,但是化学农药的滥用会造成环境污染......
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目的:阐明Cdk5介导Drp1蛋白调控线粒体功能在糖尿病视网膜病变（Diabetic Retinopathy,DR）中的作用机制;探究Drp1抑制剂Mdivi-1及Cdk5......
脑卒中（Stroke）是世界第三大致死疾病,而由缺血再灌注引起的缺血性卒中（Ischemic stroke）占所有脑卒中的80%以上。脑卒中具有极高的致......
基因表达异常所导致的神经系统早期发育失调与诸多神经疾病的发生发展（包括自闭症、精神分裂症等）存在密切关联已得到众多共识。在过......
第一部分TRIM59抑制TC45去磷酸化STAT3促进EGFR/EGFRvⅢ胶质母细胞瘤发生发展目的:EGFR/EGFRvⅢ亚型胶质母细胞瘤致病因子和致病机......
目的:糖尿病肾病（diabetic nephropathy,DN）作为一种慢性肾病,是糖尿病的严重并发症之一,也是导致终末期慢性肾病（end-stage renal di......
研究目的:研究报道,tau蛋白的磷酸化受许多蛋白激酶调节,而tau蛋白的磷酸化激酶和磷酸酶失调会导致阿尔茨海默病（Alzheimer’s dise......
目的:慢性肾脏疾病可导致渐进性、不可逆性的肾单位丢失、肾组织损伤、继而出现肾功能障碍,并最终进展至终末期肾功能衰竭,已成为......
背景:细胞周期依赖性激酶5（cycl in-dependent kinase 5,Cdk5）参与了多种神经细胞的生理过程,包括神经细胞存活、迁移、分化,轴突和......
目的 研究TGF-β1调控Cdk5表达在人肾系膜细胞外基质沉积中的作用.方法 10μg·L-1的TGF-β1刺激体外培养的人肾小球系膜细胞(HMC)......
目的 耐药是导致恶性肿瘤化学治疗失效而死亡率升高的重要原因，但耐药的分子机制尚未深入认识.肿瘤干细胞(CSC)作为一类特殊的细胞......
Tau hyperphosphorylation plays a critical role in neurodegenerative diseases....
As a representative substance of the polycyclic aromatic hydrocarbons (PAH) , benzo[a]pyrene(B[a]P) is a widely distribu......
目的：p75NTR是神经营养因子受体,可介导多种不同的细胞功能,如细胞存活、凋亡及轴突生长.这些功能的不同取决于细胞环境,配体的类型......
上皮-间质转化(EMT)是指具有极性的上皮细胞经过细胞骨架重塑,转换为具有运动能力的间质细胞并获得侵袭和迁移能力的过程,在胚胎发......
CDK5 Contributes to Neuronal Apoptosis via Promoting MEF2D Phosphorylation in Rat Model of Intracere
Background and objective:Cyclin-dependent kinase-5(CDK5) is a serine/threonine kinase activated by its neuron-specific a......
Disruption of Cdk5-Associated phosphorylation of residue threonine-161 of the delta-opioid receptor:
Morphine is the most commonly used and most effective analgesic in the clinic.However, its use is limited by the toleran......
Cyclin dependent kinase 5 contributes to inflammatory pain by promoting anterograde trafficking of T
The number of functional transient receptor potential vanilloid 1 (TRPV1) channels at the surface,especially at the peri......
Bisphenol A(BPA),a kind of representative of the environmental endocrine disruptor,is widely used for plastic products,s......
Objective.Synapse formation is crucial for learning and memory.Understanding the underlying molecular mechanisms of syna......
Deactivation of excitatory neurons in the contralateral prelimbic cortex via Cdk5 promotes pain sens
The medial prefrontal cortex(mPFC)is implicated in processing sensory-discriminative and affective pain.Nonetheless,the ......
Activation of CDK5 by noncanonical Wnt/Ca2+ signaling during neurogenesis and neuronal differentiati
Objective Canonical Wnt/β-catenin signals play important roles during neuronal differentiation and neurogenesis, but le......
Deficiency of cyclin-dependent kinase 5 (Cdk5) has been linked to the death of postmitotic cortical neurons during brain......
目的：探讨多溴联苯醚-153(BDE-153)神经毒性与calpain/p35-p25/Cdk5信号通路的关系,为多溴联苯醚神经毒性机制的研究提供科学依据.......
Chronic brain hypoperfusion(CBH)is considered as a preclinical condition of mild cognitive impairment and is thought to ......
Dissociative role for dorsal hippocampus in mediating heroin craving and relapse through CDK5 and Rh
OBJECTIVE Addiction is characterized by drug craving,compulsive drug taking and relapse,which is attributed to aberrant ......
The medial prefrontal cortex(mPFC)is implicated in processing sensory-discriminative and affective pain.Nonetheless,the ......
Systematic analysis of gene alterations and clinical outcome of cyclin-dependent kinase 5 in lung ca
Cyclin-dependent kinase 5(CDK5),a member of the cyclin-dependent kinase family,plays important role in the nervous syste......
Cyclin dependent kinase 5 mediates oligodendrocyte development, myelination and myelin repair in rod
The major function of oligodendrocytes(OLs)is the formation of myelin sheaths in the CNS.Oligodendrocytes develop fr......
Melatonin attenuates MPTP-induced neurotoxicity via preventing Cdk5-mediated autophagy and α-synucle
Autophagy is involved in the pathogenesis of neurodegenerative diseases including Parkinsons disease(PD).However,lit......
The cyclin-dependent kinase 5(CDK5)activators,p35 and p25,have a proposed role in the pathogenesis of neurodegenerat......
目的:通过观察ebselen预处理对铁诱导的SH-SY5Y细胞内tau 蛋白磷酸化影响,探讨ebselen 可以通过抑制DMT1 对二价铁离子的转运,从而......
As a representative substance of the polycyclic aromatic hydrocarbons(PAH),benzo[a]pyrene(B[a]P)is a widely distribu......
情绪障碍如恐怖症和创伤后应激障碍等源于大脑无法停止与特殊事件或连续事件相关的恐惧，甚至某些人对创伤事件的恐惧记忆越来越深刻......
目的:观察绞股蓝总皂苷对糖尿病肾脏病(DKD)大鼠巢蛋白的影响,探讨其降低蛋白尿、内生肌酐清除率、保护肾脏的机制。方法:150只雄......
目的：脯氨酸引导的丝/苏氨酸蛋白酶——细胞周期蛋白依赖性蛋白激酶5(CDK5)是细胞周期素依赖的蛋白酶家族中一个特殊成员.CDK5......
Niemann-Pick disease type C (NPC) is a fatal,neurovisceral lipid storage disease,neuropathologically characterized by cy......
阿尔茨海默病(AD)是一种神经退行性疾病,在疾病早期出现记忆障碍,随着病情进展出现严重的认知衰退,并最终导致患者在确诊后的平均9......
目的:探讨细胞周期依赖激酶-5(Cdk5)抑制剂Roscovitine对瑞芬太尼痛觉过敏大鼠痛行为学及脊髓NR2B/mGluR5磷酸化表达的影响。方法:......
每年全球有50余万例头颈部癌症新增患者,其中绝大多数的病理类型为鳞状细胞癌。晚期头颈部鳞状细胞癌常发生颈部淋巴结转移。当前,......
目的:(1)在帕金森病(Parkinson’s disease,PD)动物模型及细胞模型中探讨BRCC3的表达情况;(2)在PD细胞模型中探讨BRCC3对NLRP3炎症......
目的：将不同浓度的生长抑素类似物(奥曲肽)作用于体外培养人肝癌细胞株HepG2,观察肝癌细胞的形态变化及肝癌细胞的生长情况,于不同......
目的:明确Cdk5介导的Drp1磷酸化对线粒体形态的调控机制,及其对神经细胞功能的影响。方法:本实验选用原代神经细胞,利用Aβ1-42处......
阿尔兹海默病(Alzheimer’ s disease,AD)是一种以渐进性记忆受损和认知功能障碍为主要临床症状的神经退行性疾病。不可逆的神经元......
