stat1相关论文
支气管肺发育不良(bronchopulmonary dysplasia,BPD)属于慢性呼吸系统疾病,临床上以极早早产儿、极低出生体重儿多见。其主要特征是......
目的 探讨STAT1在激活过氧化物酶体增殖物激活受体γ(peroxisome proliferator-activated receptor γ,PPARγ)后抑制结核分枝杆菌(My......
以细胞基质生产病毒疫苗具有安全高效的特点,如鸡成纤维细胞(DF-1)、非洲绿猴肾细胞(Vero)等常用细胞作为基质在疫苗生产中发挥巨大作......
目的 总结与探讨中国大陆慢性皮肤黏膜念珠菌病(chronic mucocutaneous candidiasis, CMC)的病因、流行病学、临床特征及诊疗情况。......
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背景:乳腺癌是世界上最常见及死亡率最高的女性肿瘤之一,美国预计2020年将有276480例乳腺癌新确诊病例,占女性新确诊癌症病例的30%......
背景:肺癌不仅是全球发病率最高的恶性肿瘤疾病,其死亡率同样居所有肿瘤之首。非小细胞肺癌(Non-small cell lung cancer,NSCLC)是肺......
研究背景与目的:脓毒症(sepsis)是宿主遭受感染时所产生的失控的、持久的炎症反应,从而出现免疫失调和多器官功能损害,病情危重,预后......
目的 探讨核转录因子NF-κB(NF-κB)家族、信号转录与转录激活子1(STAT1)、调节转录因子1(ELK1)核表达对中晚期宫颈癌预后评估价值......
Circular RNAs(circRNAs),a novel class of non-coding RNAs with a loop structure,have recently been shown to participate i......
目的:狼疮性肾炎(Lupus nephritis,LN)是一种由免疫介导的复杂的器官炎症,其发病机制仍不明确。本文利用GEO(Gene Expression Omnibus......
妊娠早期胚胎丢失是困扰我国牛、羊养殖效益的主要问题之一。在反刍动物中,子宫内膜的容受性对于妊娠建立至关重要。尽管已经发现......
甲型流感病毒属于正粘病毒科,是一种分节段的单股负链RNA病毒。甲型流感病毒以呼吸道上皮细胞为目标,利用宿主细胞进行复制和传播,......
肝脏作为机体的最大的代谢器官,承担着体内新陈代谢,排毒,免疫功能和主要营养物质及胆汁分泌的功能,它在疾病的发展和进程中起着极......
目的 探讨β-arrestin2基因敲除对小鼠腹腔巨噬细胞(peritoneal macrophage,pMφ)功能的影响.方法 分别分离野生型(wild type,WT)......
目的 探究沙美特罗替卡松气雾剂结合白三烯抑制剂口服治疗对支气管哮喘患者临床疗效及外周血Toll样受体4(TLR4)、信号转导转录激活......
背景:小胶质细胞M1/M2表型失衡在许多神经变性疾病及自身免疫性疾病进展中发挥着重要作用,调节小胶质细胞表型转化是免疫治疗的靶......
背景和目的:以放射治疗为基础的治疗手段是目前多种癌症的主要治疗策略,但由于临床上放射治疗的抵抗,导致其疗效欠佳,然而目前放射......
背景在很多肿瘤中,FRAT1是不良预后的相关分子。然而,在脑胶质细胞瘤中其作用仍有争议。目的揭示STAT1和FRAT1的可能关系,并且通过......
1.研究背景动脉粥样斑块钙化(atherosclerotic calcification,AC)是在动脉粥样硬化负荷斑块内发生的钙化,是一种最常见的钙化性血管......
目的 探讨环指蛋白168(RNF168)和信号转导与转录激活因子1(STAT1)蛋白在食管鳞状细胞癌(ESCC)组织中的表达及预后观察.方法 收集20......
M1型巨噬细胞为经典活化型巨噬细胞,可分泌多种促炎因子和趋化因子促进炎症的发展.我们前期研究已经证明,630 nm发光二极管(LED)照......
为了探究去泛素化酶USP13在前列腺癌中发挥的功能及其相关分子机制,采用PCR、酶切、酶连和转化大肠杆菌等方法,成功构建USP13基因......
目的:探讨三阴性乳腺癌(three yin breast cancer,TNBC)中pSTAT1和PD-L1的表达及其相关性研究.方法:对50例三阴性乳腺癌(TNBC)、70......
目的 IL-27 是Th1型细胞因子,它可促使初始CD4+T细胞向Th1分化而抑制Th2分化,本研究通过构建哮喘模型,观察IL-27干预是否减轻过敏......
STAT1-mediated down-regulation of Bcl-2 expression is involved in IFN-γ/TNF-α-induced apoptosis in N
Tumor necrosis factor (TNF)-α and interferon (IFN)-γare the major pro-inflammatory cytokines involved in beta-cell des......
microRNA let-7c is essential for anisomycin-triggered apoptosis of human leukemic cells by linking J
Anisomycin, an antibiotic produced by Streptomyces, strongly induces apoptosis in different histological sorts of cancer......
STAT家族蛋白(The signal transducer and activator of transcription,STAT)是一种重要干扰素信号调节因子.为了能够逃逸干扰素的......
We have previously reported that endogenous (oxysterols) as well as synthetic (GW3965, TO0901317) ligands of Liver X Rec......
Altered expression of STAT1,MX and SOCS3 associated strongly with outcome of therapy in HBV infectio
Aim: To define the relativity between IFN signal pathway and outcome of antiviral treatment,we examined and compared the......
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肝细胞肝癌尤其是乙肝相关肝癌是我国目前的重大疾病,干扰素治疗是临床治疗肝癌的重要手段,但部分患者对于干扰素治疗敏感性较差,目前......
Synthesis and Biological Evaluation of Novel Berberine Derivatives as Potent Inhibitors against IFN-
To explore down-regulating IDO1 expression ability of small-molecule inhibitors in tumor cells,twenty-five novel berberi......
目的:探讨IL-35信号通路相关因子在口腔扁平苔藓中的表达及意义.方法:1.口腔扁平苔藓外周血患者40例(非糜烂型20例,糜烂型20例)和健......
The E3 ligase PIAS1 facilitates spatial learning and memory through enhanced SUMOylation of STAT1 an
We have previously found that the protein inhibitor of activated STAT1(pias1)gene is differentially expressed between th......
Sodium butyrate inhibits interferon-gamma induced indoleamine 2,3-dioxygenase expression via STAT1 i
Aims Indoleamine 2, 3-dioxygenase (IDO) inhibits T-cell proliferation by catalyzing the conversion of L-tryptophan to L-......
Background and Purposes: Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide and is among the lea......
Signal transducers and activators of transcriptions 1(STAT1) plays an important role in the inflammation process of acut......
目的 观察过氧化物酶体增殖物活化受体γ(PPARγ)激动剂罗格列酮和15脱氧前列腺素J2(15d-PGJ2)对脂多糖(LPS)诱导大鼠腹膜透析相关......
目的 探讨p-STAT1及STAT1蛋白在甲状腺癌中的表达及其与肿瘤临床病理的关系.方法 选取浙江省诸暨市人民医院江东普外科保存的甲状......
目的 分析可溶性E?选择素(sE?SLT)、可溶性细胞间粘附因子?1(sICAM?1)及信号转导和转录激活因子?1(STAT1)在小儿支气管哮喘中的表......
目的:采用生物信息学方法寻找盘状红斑狼疮(DLE)中的差异表达基因(DEGs)和免疫细胞浸润矩阵明确其功能,探讨DLE的发病机制。方法:......
Calcineurin B subunit (CnB) exerts a synergistic effect with interferon-γ in vitro and in vivo by in
We have shown previously that the calcineurin B subunit (CnB) plays an important role in innate immunity, but little......
目的 探讨地塞米松对系统性红斑狼疮(systemic lupus erythematosus,SLE)患者外周血单核细胞核蛋白中转录因子STAT1(signal transd......