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目的探讨自然周期方案行体外受精-胚胎移植(IVF-ET)在卵巢低反应患者的应用。方法对南京大学医学院附属鼓楼医院生殖医学中心2003年11月至2007年7月20例卵巢低反应患者采用自然周期方案进行IVF-ET的临床资料进行回顾性分析。结果20例患者共进行41个起始周期。其中11个周期取消,取消率为26.8%。30个取卵周期中27个周期获得卵子,取卵周期获卵率为90.0%。19个周期进行胚胎移植,起始周期移植胚胎率46.3%,取卵周期移植胚胎率63.3%。临床妊娠6例,其中5例已经分娩,1例流产。移植周期临床妊娠率为31.6%,移植周期分娩率为26.3%。结论自然周期方案行IVF-ET对于卵巢低反应患者是一种简单有效的治疗方法。
Objective To investigate the application of natural cycle IVF-ET in patients with low ovarian response. Methods The clinical data of IVF-ET using natural cycle regimen were retrospectively analyzed from 20 patients with low ovarian response in the Reproductive Medicine Center of Gulou Hospital Affiliated to Medical College of Nanjing University from November 2003 to July 2007. Results Twenty-one patients had 41 initial cycles. Among them, 11 cycles were canceled with a cancellation rate of 26.8%. Egg was acquired in 27 cycles during 30 oocyte retrieval cycles and oocyte retrieval rate was 90.0% in oocyte retrieval cycles. 19 cycles of embryo transfer, the initial cycle of embryo transfer rate of 46.3%, embryo transfer oocyte cycle rate of 63.3%. 6 cases of clinical pregnancy, of which 5 cases have been delivered, 1 case of abortion. The clinical pregnancy rate was 31.6% in the transplant cycle and 26.3% in the transplant cycle. Conclusion The natural cycle program of IVF-ET is a simple and effective treatment for patients with low ovarian response.