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壳聚糖侧链改性合成N-(4-二甲氨基苯甲基)壳聚糖(MBCS),通过葫芦[8]脲(Q[8])与MBCS侧链之间的主客体作用制得Q[8]/MBCS超分子凝胶.利用红外光谱、紫外光谱、1H NMR、X-射线粉末衍射(XRD)、热重分析(TG)和差示扫描量热(DSC)等技术对改性壳聚糖及凝胶进行表征.以5-氟尿嘧啶(5-Fu)为模型药物,研究载药凝胶在不同pH环境下的释药行为.结果表明Q[8]/MBCS体系在酸性条件下,可组装形成超分子凝胶,该凝胶体系具有温敏性和pH敏感性.扫描电镜(SEM)图显示凝胶具有网状交联结构,1H NMR谱显示,在酸性条件下,Q[8]与MBCS含氮侧链基团间发生主客体包合作用是超分子凝胶形成的主要原因.Q[8]/MBCS载药凝胶在酸性介质中对药物具有明显的缓释作用.
Synthesis of N- (4-dimethylaminobenzyl) chitosan (MBCS) by chitosan side-chain modification via the host-guest interaction between cucurbit [8] urea and MBCS side chain The Q [8] / MBCS supramolecular gel was obtained. The structure of the supramolecular gel Q [8] / MBCS was characterized by IR, UV, 1H NMR, XRD, TG and DSC. The chitosan and gel were characterized by using 5-fluorouracil (5-Fu) as a model drug to study the release behavior of drug-loaded gels under different pH conditions.The results showed that under the acidic conditions , Which can be assembled to form a supramolecular gel, the gel system has temperature sensitivity and pH sensitivity.The SEM image shows that the gel has a network cross-linked structure, 1H NMR spectrum shows that under acidic conditions, Q [8] Host-to-guest interactions between MBCS and nitrogen-containing side-chain groups of MBCS are the main causes of supramolecular gel formation. Q [8] / MBCS loaded gels have a significant sustained release of the drug in acidic media .