补中益气汤治疗脾肺阳虚型幼儿缓解期支气管哮喘随机平行对照研究

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[目的]观察补中益气汤治疗脾肺阳虚型幼儿缓解期支气管哮喘疗效。[方法]使用随机平行对照方法,将160例住院及门诊患者按抛硬币法简单随机分为两组。对照组80例奈德福莫特罗,4.5μg/次,2次/d;沙丁胺醇,100μg/次,3次/d。治疗组80例补中益气汤(柴胡8g,白术10g,丹参、生黄芪各20g,当归8g,升麻10g,桃仁15g,人参8g,甘草炙10g,陈皮8g),1剂/d,水煎100mL,早晚饭后口服,50mL/次。连续治疗45d为1疗程。观测临床症状、FVC、FEV_1、FEF、不良反应。治疗1疗程,判定疗效。[结果]治疗组痊愈44例,显效23例,有效10例,无效3例,总有效率96.25%。对照组痊愈23例,显效19例,有效14例,无效24例,总有效率70.00%。治疗组疗效优于对照组(P<0.01)。肺功能指标治疗组均有改善(P<0.01);对照组FEV1无明显变化(P>0.05),其他均明显改善(P<0.01);治疗组改善优于对照组(P<0.01)。[结论]补中益气汤治疗脾肺阳虚型幼儿缓解期支气管哮喘疗效满意,无严重不良反应,值得推广。 [Objective] To observe the effect of Buzhong Yiqi Decoction on bronchial asthma in remission children with spleen-lung-yang deficiency syndrome. [Methods] Using randomized parallel control method, 160 inpatients and outpatients were randomly divided into two groups according to the coin tossing method. In the control group, 80 cases were treated with nedoxetolol, 4.5μg / time, twice daily, salbutamol, 100μg / time and 3 times daily. The treatment group 80 cases of Buzhong Yiqi Tang (Bupleurum 8g, Atractylodes 10g, Salvia, raw Astragalus 20g, angelica 8g, cohosh 10g, peach kernel 15g, ginseng 8g, licorice Sunburn 10g, orange peel 8g), 1 / Decoction 100mL, morning and evening after oral administration, 50mL / times. Continuous treatment of 45d for a course of treatment. Observation of clinical symptoms, FVC, FEV_1, FEF, adverse reactions. Treatment of a course of treatment to determine the efficacy. [Result] In the treatment group, 44 cases were cured, 23 cases were markedly effective, 10 cases were effective, 3 cases were ineffective, and the total effective rate was 96.25%. The control group cured 23 cases, 19 cases markedly effective in 14 cases, 24 cases were ineffective, the total effective rate was 70.00%. The treatment group than the control group (P <0.01). (P <0.01). There was no significant change in FEV1 in the control group (P> 0.05), and the others were significantly improved (P <0.01). The improvement in the treatment group was better than that in the control group (P <0.01). [Conclusion] Buzhong Yiqi Decoction is effective in relieving bronchial asthma in children with spleen-lung-yang deficiency type and has no serious side effects and is worth promoting.
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