论文部分内容阅读
目的:比较IIb期宫颈癌行根治术联合术前同期放化疗与根治性放疗联合同期化疗的临床疗效。方法:回顾分析2002年7月-2008年12月我院收治的79例IIb期宫颈癌患者,48例行根治手术结合术前同期放化疗(观察组),31例行根治性放疗结合同期化疗(对照组)。结果:观察组的5年总生存率(OS)为83.3%,5年无进展生存率(PFS)为79.2%,对照组则分别为58.1%、54.8%,两组比较差异有统计学意义。观察组复发率(20.8%)较对照组(45.2%)明显降低(P<0.05)。观察组下肢水肿发生率较高,对照组放射性肠炎、膀胱炎发生率较高,差异有统计学意义(P<0.05),两组患者肠梗阻、泌尿生殖道瘘发生率差异无统计学意义(P>0.05)。结论:IIb期宫颈癌患者,根治术联合术前同期放化疗能获得较长生存期。虽然增加了下肢水肿发生率,但减少了放射性肠炎、膀胱炎发生率。
Objective: To compare the clinical efficacy of concurrent radical resection with radiotherapy combined with radical radiotherapy in the treatment of stage IIb cervical cancer. Methods: A retrospective analysis of 79 patients with stage IIb cervical cancer treated in our hospital from July 2002 to December 2008 was performed. 48 patients underwent radical surgery combined with preoperative radiotherapy and chemotherapy (observation group), 31 patients underwent radical radiotherapy combined with concurrent chemotherapy (Control group). Results: The 5-year overall survival (OS) was 83.3% in the observation group and 79.2% in the 5-year progression-free survival and 58.1% and 54.8% in the control group respectively. There was significant difference between the two groups. The recurrence rate (20.8%) in observation group was significantly lower than that in control group (45.2%) (P <0.05). The incidence of lower extremity edema in observation group was higher than that in control group, the incidence of radiation enteritis and cystitis was higher (P <0.05) P> 0.05). Conclusion: Patients with stage IIb cervical cancer, radical surgery combined with preoperative radiotherapy and chemotherapy can achieve longer survival. Although increasing the incidence of lower extremity edema, but reduce the incidence of radiation enteritis, cystitis.