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目的:观察无环鸟苷治疗慢性乙型肝炎的疗效。方法:无环鸟苷治疗组25例,用无环鸟苷10mg/kg/d,分两次静滴,3个月为一疗程;对照组27例。HBVM检测用ELISA法,HBV-DNA采用生物素探针班点杂交法。结果:在治疗结束时、随访半年、1年、2年和3年,无环鸟苷治疗的总有效率(HBeAg和/或HBV-DNA阴转)分别为36.0%、32%、32%、30.4%和33.3%,显著高于对照组(7.4%,P<0.05)。结论:无环鸟苷治疗慢性乙型肝炎确有一定的疗效。
Objective: To observe the curative effect of acyclovir on chronic hepatitis B Methods: Acyclovir treatment group of 25 cases, with acyclovir 10mg / kg / d, two intravenous infusion, three months for a course of treatment; control group of 27 cases. HBVM detection by ELISA method, HBV-DNA by biotin probe spot hybridization method. Results: At the end of treatment, the total effective rate of acyclovir treatment (HBeAg and / or HBV DNA negative conversion) was 36.0%, 32%, 32% at follow-up of 6 months, 1 year, 2 years and 3 years respectively %, 30.4% and 33.3% respectively, which was significantly higher than that of the control group (7.4%, P <0.05). Conclusion: Acyclovir treatment of chronic hepatitis B does have a certain effect.