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目的观察分析抗乙肝免疫核糖核酸加乙肝疫苗治疗慢性乙肝疗效的临床效果。方法将自2013年12月至2014年11月间在我院接受治疗的43例慢性乙肝患者为研究对象,按自愿原则将患者分组,并在治疗后对观察指标内容进行统计分析。结果采用抗乙肝免疫核糖核酸加乙肝疫苗治疗患者的HBeAg转阴率为36.36%显著优于采用抗乙肝免疫核糖核酸治疗对照组的23.81%,P<0.05;观察组的ALT复常率和HHBV DNA低于检测下线率均优于对照组,P<0.05;均有统计学意义。结论在慢性乙肝治疗中采用抗乙肝免疫核糖核酸加乙肝疫苗联合用药方法可获得较好的HBeAg转阴率,且综合疗效显著。体会慢性乙肝的治疗过程较为漫长,采用本研究用药可获得一定的效果,但治疗中仍应进行各方面如饮食生活等的综合治疗。
Objective To observe and analyze the clinical effect of anti-hepatitis B immune RNase plus hepatitis B vaccine in the treatment of chronic hepatitis B. Methods From December 2013 to November 2014 in our hospital for treatment of 43 cases of chronic hepatitis B patients as the research object, according to the principle of voluntarily, patients were divided into groups, and after treatment, the contents of the observation indicators were statistically analyzed. Results HBeAg negative rate was 36.36% in patients treated with anti-hepatitis B immune RNase plus hepatitis B vaccine, which was significantly better than 23.81% of the control group treated with anti-hepatitis B immune RNA, P <0.05. The ALT normalization rate and HHBV DNA Lower than the detection rate under line were better than the control group, P <0.05; all were statistically significant. Conclusions The combination of anti-hepatitis B immunization plus hepatitis B vaccine can achieve better HBeAg negative rate in the treatment of chronic hepatitis B, and the comprehensive curative effect is remarkable. Experience of chronic hepatitis B treatment process is relatively long, the use of this study can get some results, but the treatment should still be carried out in all aspects such as diet and comprehensive treatment.