论文部分内容阅读
近年来,克隆病(CD)由分枝杆菌引起的概念重新引起注意。有病例报道抗结核药物可能对CD有用。早在70年前即有人指出,CD的组织病理学表现提示分枝杆菌属感染,但病变组织中分离出细菌则迟至本世纪七十年代始有报道。分枝杆菌也曾从溃疡性结肠炎和对照组织中分离,但这不应使人惊奇。鸟细胞内分支杆菌复体(MAIC)普遍存在,且常在AIDS患者中造成重复感染。最引人注意的是致病性副结核分支杆菌的分离。它是Johne病(?)(发生于反刍动物的局限性小肠炎)的病原体,也曾从3个医学中心的7例CD中分离,它与鸟分枝杆菌的鉴别问题长期未能解决,但近年应用DNA杂交技术证明,CD组织中分离出的副结核分支杆菌与反刍动物中的致病株相同,而与MAIC菌不同。此外,Johne病曾在灵长类动物中发现,Morgan并指出Johne病与CD的病因学甚为相似。
In recent years, the concept of Crohn’s disease caused by mycobacteria has drawn renewed attention. There are case reports that anti-TB drugs may be useful for CDs. As early as 70 years ago, it was pointed out that the histopathological manifestations of CD prompted Mycobacterium infection, but the isolation of bacteria in diseased tissue is late until the seventies of this century has been reported. Mycobacteria have also been isolated from ulcerative colitis and control tissues, but this should not surprise people. Bird intracellular mycobacterial complex (MAIC) is ubiquitous and often causes repeated infections in AIDS patients. The most notable is the isolation of pathogenic Parain Mycobacterium paratuberculosis. It is the causative agent of Johne’s disease (?) (Localized enteritis in ruminants) and has also been isolated from 7 CDs in three medical centers and its identification with Mycobacterium avium has not been resolved for a long time, but In recent years, the use of DNA hybridization proved that the Mycobacterium paratuberculosis isolated from CD tissue is the same as the pathogenic strain in ruminants but different from that of MAIC bacteria. In addition, Johne’s disease was found in primates, and Morgan pointed out that Johne’s disease is very similar to the etiology of CD.