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细胞间粘附分子所介导的白细胞与内皮细胞之间的粘附与缺血再灌注脑损伤关系密切。粘附分子的表达受炎性细胞因子的诱导。着重介绍了缺血再灌注脑损伤中多种粘附分子的重要意义以及粘附分子介导的内皮细胞、白细胞粘附增强在脑损伤中的病理过程,并探讨防止和减轻粘附分子作用的对策。
Intercellular adhesion molecule-mediated adhesion between leukocytes and endothelial cells and ischemia-reperfusion brain injury are closely related. Expression of adhesion molecules is induced by inflammatory cytokines. The importance of multiple adhesion molecules in brain injury induced by ischemia-reperfusion and the pathological process of adhesion molecules-mediated enhancement of adhesion of endothelial cells and leukocytes to brain injury are emphatically introduced, and the roles of adhesion molecules in preventing and reducing adhesion molecules Countermeasures.