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对40例血栓性脑梗塞患者、32例患者一级亲属、14例患者配偶的血浆PGI_2、TXA_2水平进行了研究,显示出男、女患者均有PGI_2-TXA_2平衡紊乱,男性患者以TXA_2增高为主,女性患者以PGI_2降低为主。PGI_2降低和/或TXA_2增高所致的PGI_2-TXA_2平衡紊乱与遗传因素有一定关系。并为PGI_2降低和/或TXA_2增高在血栓性脑梗塞的发病中起一定作用提供了佐证。
The levels of plasma PGI_2 and TXA_2 in 40 thrombotic cerebral infarction patients, 32 first-degree relatives and 14 spouses were studied. The PGI_2-TXA 2 balance disorder was found in both males and females, and the male patients with TXA 2 increased Main and female patients to reduce PGI_2. PGI_2 and / or elevated TXA_2 PGI_2-TXA_2 balance disorder and genetic factors have a certain relationship. And provide evidence for the decrease of PGI 2 and / or the increase of TXA 2 in the pathogenesis of thrombotic cerebral infarction.