论文部分内容阅读
目的探讨慢性丙型肝炎患者干扰素治疗前后血清自身抗体的合并状况。方法回顾性分析2005年2月-2008年2月66例慢性丙型肝炎患者应用干扰素治疗前后的检测结果,观察治疗前后自身抗体合并状况及与干扰素疗效的关系。结果①66例慢性丙型肝炎患者中39例自身抗体阳性,阳性率59.1%(39/66),主要为ANA;②自身抗体的产生与年龄相关,而与性别、HCVRNA定量无关;③自身抗体阳性组干扰素应答率66.7%(26/39)明显高于阴性组40.7%(11/27),二者比较差异有统计学意义;④干扰素治疗后,自身抗体阴性组自身抗体检出率为44.4%(12/27),但滴度均<1∶320;治疗前抗甲状腺球蛋白抗体阳性患者会出现较高的甲状腺功能异常率。结论慢性丙型肝炎合并血清自身抗体阳性的患者干扰素应答率高于阴性组,但应注意抗甲状腺球蛋白抗体,以预测不良反应。
Objective To investigate the combined status of serum autoantibodies in patients with chronic hepatitis C before and after interferon treatment. Methods A retrospective analysis of 66 patients with chronic hepatitis C from Feb. 2005 to Feb. 2008 was conducted before and after treatment with interferon. The correlation between autoantibodies and the efficacy of interferon before and after treatment were observed. Results ① Of the 66 patients with chronic hepatitis C, 39 were positive for autoantibodies, the positive rate was 59.1% (39/66), mainly ANA. ② The production of autoantibodies was related to age, but not to the sex and HCVRNA. ③ The autoantibodies were positive Interferon response rate of 66.7% (26/39) was significantly higher than the negative group 40.7% (11/27), the difference was statistically significant; ④ interferon treatment, autoantibody negative autoantibody detection rate was 44.4% (12/27), but the titers were all less than 1: 320. Patients with anti-thyroglobulin antibody positive had higher rates of thyroid dysfunction before treatment. Conclusion The response rate of interferon in chronic hepatitis C patients with positive serum autoantibody is higher than that in negative group, but anti-thyroglobulin antibody should be paid attention to predict the adverse reaction.