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为了研究原发性震颤确切的阳性家族史发生率,作者对319例原发性震颤(ET)患者进行了随访研究。所有ET患者均有家族史的完整资料。阳性家族史指在一级亲属中至少有一位ET患者。首先在诊所询问患者,数月以后通过电话或写信了解一级亲属ET的发病情况。结果表明,在诊所询问的319例ET中,216例(67.7％)有阳性家族史,并对103例阴性家族史患者的亲属进行了随访。第一次随访除15例因死亡或其它原因退组外,其余的88例中17例有阳性家族史。第二次随访的71例中,51例退组,而10例有阳性家族史。这样,在以后二次随访中,66例自动退组,现存的253(319-66)例ET中243(216+17+10)例ET患者有
To investigate the exact positive family history of primary tremor, we conducted a follow-up study of 319 patients with essential tremor (ET). All ET patients have a complete history of family history. Positive family history refers to at least one ET patient in first-degree relatives. First in the clinic to ask patients, a few months later by phone or write letter to understand the incidence of first-degree relatives ET. The results showed that of the 319 ETs in the clinic, 216 (67.7%) had a positive family history and were followed up by 103 relatives of patients with a negative family history. The first follow-up except for 15 cases of death or other reasons because of the withdrawal, the remaining 88 cases in 17 cases of positive family history. Of the 71 patients who were followed up for the second time, 51 were withdrawn and 10 had a positive family history. In this way, in the second follow-up, 66 patients were withdrawn automatically. There are 243 (216 + 17 + 10) ET patients in the 253 (319-66) ET patients