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为寻找具有生理活性的Troponoids,选择 3 乙酰基酚酮 1和2 乙酰基 7 甲胺基酮 6与 3,4 ,5 三甲氧基苯甲醛等取代醛反应得到缩合产物 2～ 5,7～ 9;缩合产物 3 (3,4 ,5 三甲氧基 )肉桂酰基酚酮 2和 3 (3,4 亚甲二氧基 )肉桂酰基酚酮 4与羟氨和苯肼进行缩合成环得到苯乙烯基取代的缩杂环酮化合物 10～ 13;化合物 1与 3,4 ,5 三甲氧基苯甲醛在原甲酸三乙酯和高氯酸存在下反应一步得到 2 (3,4 ,5 三甲氧基 )苯基 4 ,9 二氢环庚并吡喃 4 ,9 二酮 14。以上化合物 2～ 5,7～ 14的结构经光谱分析和元素分析予以证实
In order to find physiologically active Troponoids, 3 acetylchololone 1 and 2 acetyl 7 methylaminomethyl ketone 6 were reacted with substituted aldehydes such as 3,4,5-trimethoxybenzaldehyde to obtain condensation products 2 ~ 5,7 ~ 9; Condensed product 3 (3,4,5 trimethoxy) cinnamoyl isophenone 2 and 3 (3,4 methylenedioxy) cinnamoyl isophenol 4 condensed with hydroxylamine and phenylhydrazine into a ring To obtain the styryl substituted heterocyclyl compounds 10-13; reacting compound 1 with 3,4,5 trimethoxybenzaldehyde in the presence of triethyl orthoformate and perchloric acid to give 2 (3,4,5 Trimethoxy) phenyl 4,9-dihydrocycloheptapyran 4,9 dione 14. The structures of compounds 2 ~ 5 and 7 ~ 14 above were confirmed by spectral analysis and elemental analysis