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该文研究消化性溃疡患者HP感染与IL－6、IL－8细胞因子的活性及炎症反应的关系。方法：胃镜下，在溃疡周边取胃粘膜组织进行HP尿素酶反应、病理检查和制备胃粘膜培养液，并用ELISA夹心法检测IL-6、IL－8活性。结果：消化性溃疡患者HP感染占88％．无感染的溃疡患者占12％，HP感染（＋＋＋）占38％；HP感染溃疡患者胃粘膜IL－6、IL－8活性均显著高于对照组和HP阴性组（P＜0．05）；HP根除后胃粘膜IL-6、IL8活性降低，与根除前相比有明显差异（P＜0．05）；HP感染（＋）、（＋＋）、（＋＋＋）IL－6、IL－8活性逐渐增加（P＜0．05）；胃粘膜炎症细胞浸润（＋）、（＋＋）、（＋＋＋），胃粘膜IL－6、IL－8活性亦有显著性差异（P＜0．05），依次为（＋＋＋）＞（＋＋）＞（＋）。结论：消化性溃疡患者胃粘膜炎症活动程度和IL－6、IL－8活性均随HP感染密度加大而增加；IL－6、IL－8参与HP感染的炎症及应，在溃疡形成中可能起重要作用。
This article studies the relationship between HP infection and IL-6, IL-8 cytokine activity and inflammatory reaction in patients with peptic ulcer. Methods: Gastroscopy was used to detect the activity of IL-6 and IL-8 in the gastric mucosa. The urease reaction, pathological examination and gastric mucosa culture were performed. Results: HP infection in patients with peptic ulcer accounted for 88%. HP infection (+++) accounted for 12% of patients with uninfected ulcer and IL-6 and IL-8 activity of gastric ulcer in patients with HP-infected ulcer were significantly higher than those in control group and HP-negative group (P <0.05); The activity of IL-6 and IL-8 in gastric mucosa decreased after HP eradication, which was significantly different from that before eradication (P <0.05). HP infection (+), (++), (+++) (+), (++), (+++), IL-6 and IL-8 in gastric mucosa were significantly increased (P <0.05) The order is (+++)> (++)> (+). Conclusion: Gastric mucosal inflammatory activity and IL-6 and IL-8 activity in patients with peptic ulcer increase with the increase of HP infection density. IL-6 and IL-8 are involved in the inflammation of HP infection and should be in the formation of ulcer makes an important impact.