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应用高效液相色谱法测定了１２例恶性脑瘤患者及１２例正常人血浆氨基酸摩尔浓度，结果脑瘤患者血浆氨基酸水平发生明显改变。其特点为：ａ．血浆氨基酸总量明显下降，必需氨基酸和非必需氨基酸同时减少．ｂ．芳香族氨基酸含量升高，分支氨基酸及含硫氨基酸无明显改变．ｃ．甘氨酸、精氨酸和生糖氨基酸含量减少．结果表明血浆氨基酸的紊乱与恶性脑瘤的恶病质有关，纠正氨基酸代谢紊乱有助于临床治疗．
The plasma amino acid concentrations of 12 patients with malignant brain tumor and 12 normal individuals were determined by HPLC. The result showed that the plasma amino acid levels in patients with brain tumor significantly changed. Its characteristics are: a. Total plasma amino acids decreased significantly, essential amino acids and non-essential amino acids simultaneously reduced. b. Aromatic amino acids increased, branching amino acids and sulfur-containing amino acids no significant change. c. Glycine, arginine and glycoengine amino acid content decreased. The results show that the plasma amino acid disorder and cachexia of malignant brain tumors, to correct amino acid metabolism disorders contribute to clinical treatment.