稀土掺杂无机纳米晶由于其高光化学稳定性、生物兼容性、长荧光寿命和可调谐荧光发射波长等优点,有望成为替代分子探针的新一代荧光生物标记材料。目前国内外对稀土纳米荧光标记材料的研究大都局限在NaYF4等稀土掺杂氟化物纳米晶,对于具有良好生物相容性的超小(<10 nm)无机氧化物基纳米荧光标记材料的制备一直 Rare earth doped inorganic nanocrystals are expected to be a new generation of fluorescent biomarker materials replacing molecular probes because of their high photochemical stability, biocompatibility, long fluorescence lifetime and tunable fluorescence emission wavelength. At present, the researches on rare earth nano fluorescently labeled materials are mostly confined to rare earth doped fluoride nanocrystals such as NaYF4. The preparation of ultra-small (<10 nm) inorganic oxide based nanofluorescent labeling materials with good biocompatibility