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目的探讨尿毒症患者中血小板胞内游离钙（Pt［Ca(2+)］i）与血压的相互关系。方法应用Frua-2荧光法测定了24例尿毒症患者（其中高血压组14例，非高血压组10例）透析前后Pt［Ca(2+)］i。结果发现高血压组透析前Pt［Ca（2+)］i与收缩压（SBP）和平均动脉压（MAP）有密切相关（γ＝0.91、P＜0．01和γ＝0.63，P＜0．05），而高血压组透析后及非高血压组透析前后Pt［Ca(2+)］i和SBP、MAP之间无相关性。透析前高血压组Pt［Ca(2+)］i显著高于非高血压组（P＜0.01）。结论尿毒症病人血压升高与Pt［Ca(2+)］i有线性相关关系，Pt［Ca(2+)］i静息水平的提高可能与尿毒症患者高血压的发生和发展有关。
Objective To investigate the relationship between platelet intracellular free calcium (Pt [Ca (2 +)] i) and blood pressure in uremic patients. Methods The concentration of Pt [Ca (2 +)] i in 24 patients with uremia (including 14 in hypertensive group and 10 in non-hypertensive group) was determined by Frua-2 fluorescence spectrometry before and after dialysis. The results showed that Pt [Ca (2 +)] i was closely related to systolic pressure (SBP) and mean arterial pressure (MAP) in hypertensive patients before dialysis (γ = 0.91, P <0.01 and γ = .05). There was no correlation between Pt [Ca (2 +)] i and SBP and MAP before and after dialysis in hypertension group and non-hypertension group. Pretreatment hypertension group Pt [Ca (2 +)] i was significantly higher than non-hypertensive group (P <0.01). Conclusions There is a linear relationship between the increase of blood pressure and Pt [Ca (2 +)] i in patients with uremia. The increase of resting level of Pt [Ca (2 +)] i may be related to the occurrence and development of hypertension in patients with uremia.