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胃溃疡(Gastric Ulcer GU)和胃癌(Gastrio Cancer Gc)均是我国乃至全世界人群中的常见病、多发病。近年来,虽然胃溃疡的发病率开始呈下降趋势,但仍属消化系统疾病中最常见的疾病之一,目前已被认为是癌前病变之一。据统计,5%左右的胃溃疡可发生癌变,甚至有统计最高达29.4%的胃癌来自胃溃疡[1]。在世界范围内恶性肿瘤中,胃癌位居第4,病死率位居第2,在我国则居第1位。胃癌发生的分子机制研究表明多基因变异是细胞发生癌变的内因[2]。各种癌基因、抑癌基因和错配修复基因、细胞信号传导通路的异常、细胞周期调控改变及相关产物均对胃癌的发生发展产生影响。如Survivin、DNA甲基化和CD44等均是近年来在胃癌组织中发现的并成为研究热点的基因。通过对Survivin、Dnmt和CD44三种基因在胃溃疡及胃癌中表达的差异的了解,有助于加深对胃癌发生、发展及转移机制的认识,更好的为临床应用中胃溃疡及胃癌的治疗提供理论依据和找到更好的治疗方法。
Gastric Ulcer GU and Gastrio Cancer Gc are both common and frequently occurring in people in China and around the world. In recent years, although the incidence of gastric ulcer began to decline, but still one of the most common diseases of digestive diseases, has now been considered as one of the precancerous lesions. According to statistics, about 5% of gastric ulcer carcinogenesis may occur, and even up to a statistical maximum of 29.4% of gastric cancer from gastric ulcer [1]. Among the malignant tumors in the world, gastric cancer ranks the 4th, with the highest mortality rate in China and the first in China. The molecular mechanism of gastric cancer research shows that multiple gene mutations is the internal cause of cancer cells [2]. A variety of oncogenes, tumor suppressor genes and mismatch repair genes, cell signaling pathway abnormalities, changes in cell cycle regulation and related products have an impact on the occurrence and development of gastric cancer. Such as Survivin, DNA methylation and CD44 are all found in gastric cancer tissue in recent years and become a hot research gene. The understanding of the differences in the expression of Survivin, Dnmt and CD44 in gastric ulcer and gastric cancer will help to deepen the understanding of the mechanism of gastric carcinogenesis, development and metastasis, and better for the treatment of gastric ulcer and gastric cancer in clinical application Provide a theoretical basis and find a better treatment.