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目的了解马山县结核分枝杆菌耐药基线水平,为结核病防治工作提供科学依据。方法应用比例法对结核分技杆菌进行药敏试验,药敏试验药物为异烟肼、利福平、乙胺酊醇、链霉素、氧氟沙星、卡那霉素。结果一线抗结核药总耐药为23.81%(15/63);初始耐药率为23.91%(11/46),获得性耐药率为23.53%(4/17);多耐药率为6.35%(4/63),耐多药率为7.94%(5/63),广泛耐药率为3.17%(2/63);初治复治患者在总耐药、耐多药差异均没有统计学意义(χ2=0.000～1.460,P>0.05);耐药水平从高到低顺位为异烟肼17.46%(11/63)、利福平11.11%(7/63)、链霉素11.11%(7/63)、乙胺酊醇7.89%(5/63)、,卡那霉素1.59%(1/63)、氧氟沙星1.59%(1/63)。结论马山县结核分枝杆菌耐药情况低于全国平均水平,但耐多药肺结核的防治应引起重视。
Objective To understand the baseline level of Mycobacterium tuberculosis resistance in Mashan County and provide a scientific basis for tuberculosis prevention and treatment. Methods The sensitivity test was carried out on the Fusobacterium tuberculosis by the proportional method. The drug sensitivity test drugs were isoniazid, rifampicin, ethinol, streptomycin, ofloxacin and kanamycin. Results The first-line anti-TB drug resistance was 23.81% (15/63), the initial drug resistance rate was 23.91% (11/46), and the acquired resistance rate was 23.53% (4/17). The multi-drug resistance rate was 6.35 (4/63), the rate of multi-drug resistance was 7.94% (5/63) and the rate of extensive drug resistance was 3.17% (2/63). There was no statistical difference between the two groups (Χ2 = 0.000-1.460, P> 0.05). The levels of resistance were 17.46% (11/63) for isoniazid, 11.11% (7/63) for rifampicin, 11.11 for streptomycin (7/63), ethylamine tincture alcohol 7.89% (5/63), kanamycin 1.59% (1/63), ofloxacin 1.59% (1/63). Conclusion The prevalence of Mycobacterium tuberculosis in Mashan County is lower than the national average, but the prevention and treatment of MDR-TB should be taken seriously.