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目的探讨免疫组化指标在卵巢肿瘤诊断中的应用价值。方法选取病理诊断为支持-间质细胞瘤、卵巢子宫内膜样腺癌的石蜡标本各44例,分别为实验组和对照组,进行常规石蜡制片,用肌酸激酶(CK)、波形蛋白(Vimentin)、CD99、抑制素-α(Inhibin-α)进行免疫组化染色并对染色结果进行镜下观察分析。结果 CK、Inhibin-α及CD99在两种不同肿瘤细胞中的表达率差异具有统计学意义(P<0.05),而Vimentin表达率差异无统计学意义(P>0.05)。结论 CD99、CK、Inhibin-α在卵巢支持-间质细胞瘤和卵巢子宫内膜样腺癌的诊断及鉴别诊断中具有重要意义和临床应用价值,而Vimentin意义不大。
Objective To investigate the value of immunohistochemistry in the diagnosis of ovarian tumors. Methods Forty-four paraffin-embedded specimens of stromal tumors of the ovary and endometrioid adenocarcinoma of the ovary were selected for pathological diagnosis. The paraffin-embedded specimens were divided into experimental group and control group respectively. The paraffin-embedded specimens were prepared with creatine kinase (CK), vimentin Vimentin, CD99 and Inhibin-α were detected by immunohistochemical staining and microscopic observation. Results The expression rates of CK, Inhibin-α and CD99 in two kinds of tumor cells were significantly different (P <0.05), while there was no significant difference in the expression of Vimentin (P> 0.05). Conclusions CD99, CK and Inhibin-α are of great significance and clinical value in the diagnosis and differential diagnosis of ovarian support-stromal cell carcinoma and ovarian endometrial adenocarcinoma, but Vimentin is of little significance.