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目的探讨乌司他丁对慢性阻塞性肺疾病急性加重期(AECOPD)炎性细胞因子的影响。方法慢性阻塞性肺疾病急性加重患者随机分为两组,治疗组在综合治疗基础上加用乌司他丁,对照组为综合治疗,治疗前后观察血清细胞因子(IL-8、TNF-α、IL-6)的变化。结果两组治疗后均能降低血清TNF-α、IL-8、IL-6的表达,且治疗组优于对照组。结论乌司他丁能降低AECOPD患者血清中IL-8、TNF-α、IL-6的表达。
Objective To investigate the effect of ulinastatin on inflammatory cytokines in acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Methods Patients with acute exacerbation of chronic obstructive pulmonary disease were randomly divided into two groups. The treatment group was treated with ulinastatin on the basis of comprehensive treatment and the control group was comprehensive treatment. Serum levels of cytokines (IL-8, TNF-α, IL-6) changes. Results After treatment, the serum levels of TNF-α, IL-8 and IL-6 in both groups were significantly lower than those in the control group. Conclusion Ulinastatin can reduce the serum levels of IL-8, TNF-α and IL-6 in AECOPD patients.