作者联用ＩＦＮ－α和利巴韦林治疗单用ＩＦＮ－α治疗无应答的抗－ＨＢｅ阳性的慢性乙型肝炎病人,并观察了其远期疗效,同时对单用ＩＦＮ－α治疗无应答的原因作了研究。方法２４例慢性乙型肝炎患者为研究对象,他们均已接受过ＩＦＮ－α治疗４~６个月,其中１９例还接受过６个月ＩＦＮ－β的第二次治疗,谷丙转氨酶(ＡＬＴ)升高,抗－ＨＢｅ/ＨＢＶ－ＤＮＡ阳 The authors treated IFN-α and ribavirin alone with anti-HBe positive chronic hepatitis B patients treated with IFN-α and observed their long-term efficacy, while not responding to IFN-α alone The reason has been studied. Methods Twenty-four patients with chronic hepatitis B were enrolled in the study. All of them had been treated with IFN-α for 4 to 6 months. Among them, 19 patients received the second treatment of IFN-β for 6 months. Alanine aminotransferase (ALT ), Anti-HBe / HBV-DNA positive