青年型牙周病最严重,破坏性最大,由于病因不明,治疗效果不理想,长期以来一直是一个困难的问题。近几年来,牙周病发病原理与免疫反应的可能关系受到了重视。1965年Brandtzaeg和Kraus用萤光免疫技术,证明了在健康的和发炎的牙龈组织中,免疫球蛋白的含量不相同。1970年Ranney等用卵白蛋白作为刺激原在恒河猴的牙龈沟 Youth type periodontal disease is the most serious and destructive, due to unknown etiology, the treatment is not satisfactory, has long been a difficult issue. In recent years, the pathogenesis of periodontal disease and the possible relationship between immune response has been valued. In 1965 Brandtzaeg and Kraus used fluorescent immunofluorescence to demonstrate that immunoglobulins were not the same in healthy and inflamed gingival tissues. In 1970, Ranney et al used ovalbumin to stimulate the gingival sulcus in rhesus monkeys