HISTONE相关论文
Aim: To simultaneously determine the localization of histones and protamines within human sperm nuclei. Methods: Immunof......
The histone H3 Lys 27 (H3K27) demethylase JMJD3 has been shown to play important roles in transcriptional regulation and......
Our previous study revealed that PDCD2 plays a role in erythroid differentiation (unpublished data).To get a further vie......
Preparation and characterization of DNA aptamer based enrichment column for recognition and separati
It is well known that the protein, especially the one which has some post-translational modifications, is available to b......
Senile plaques(SPs)are one of the pathological features of Alzheimer\'s disease(AD)and they are formed by the overprod......
The combination of chidamide with the CHOEP regimen in previously untreated patients with peripheral
Objective:To assess the efficacy and safety of the novel histone deacetylase inhibitor,chidamide,in combination with cyc......
Primary malignant brain tumors are a major cause of morbidity and mortality in both adults and children,with a dismal pr......
A domesticated Harbinger transposase forms a complex with HDA6 and promotes histone H3 deacetylation
In eukaryotes,histone acetylation is a major modification on histone N-terminal tails that is tightly connected to trans......
Aberrant epigenetic alterations play a decisive role in cancer initiation and propagation via the regulation of key tumo......
Histone deacetylase 6 delays motor neuron degeneration by ameliorating the autophagic flux defect in
Amyotrophic lateral sclerosis(ALS) is a fatal neurodegenerative disorder characterized by the selective loss of motor ne......
Proportions of acetyl-histone-positive hepatocytes indicate the functional status and prognosis of c
AIM:To investigate whether the proportions of acetylhistone-positive hepatocytes could be used as markers of deteriorati......
Study the effects of metallic ions on the combination of DNA and histones with molecular combing tec
The effects of monovalent (Na+, K+) and divalent (Mg2+, Ca2+, Mn2+) ions on the interaction between DNA and histone are ......
阳离子的绑定(Na+ ， K+ ， Mg2+ ， Ca2+ ， Mn2+) 并且到 DNA 的 histones 能用荧光试金被学习。这里，我们面对阳离子测量了 DNA 和 DNA-h......
目的 体外观察组蛋白脱乙酰基酶抑制剂Panobinostat对前列腺癌细胞系LNCaP、PC-3的X线放射增敏效应,并初步探讨其作用机制.方法 用......
Histone post-modifications are important epigenetic markers involved in multiple cellular processes via regulation of ge......
The anticancer therapies with the joint treatment of a histone deacetylase(HDAC) inhibitor and a DNA-damaging approach a......
Background Several clinical studies have shown that smoking in asthmatics and chronic obstructive pulmonary disease pati......
组蛋白抗体(histone antibodies,HAb)由Kunkel等于1960年,用补体结合反应在系统性红斑狼疮(SLE)患者的血清中首次发现。本文作者......
Histone deacetylases(HDACs) are considered to be among the most promising targets for the development of anti-cancer dru......
Over the past years,it has been found that the epigenetic silence of tumor suppressor genes induced by overexpression of......
Structure-based design of conformationally constrained cyclic peptidomimetics to target the MLL1-WDR
We described herein structure-based design,synthesis and evaluation of conformationally constrained,cyclic peptidomimeti......
Determination and stress studies on YK-1101,a potential histone deacetylase,by HPLC-UV and HPLC-TOF/
YK-1101,with its structure as S-((E)-4-((7S,10S,Z)-4-ethylidene-7-isopropyl-2,5,8,12tetraoxo-9-oxa-16-thia-3,6,13,18-tet......
组蛋白去乙酰化酶抑制剂(histone deacetylase inhibitors,HDACI)作为一类非细胞毒性新型抗肿瘤的靶向治疗药物备受关注,其抗肿瘤......
Objective: To explore the protection and molecular mechanism of histone deacetylase inhibitors(HDACIs) on the spleen of ......
Histone H2 A methylation at Gln104(H2AQ104Me) is a new type of histone post-translational modification(PTM) discovered r......
A new ureido-substituted amino acid,conopsamide A(1),has been isolated from an ethanolic extract of the tubers of Gymnad......
Expression Profiles of SIRT1 and APP Genes in Human Neuroblastoma SK-N-SH Cells Treated with Two Epi
In our previous studies, significant hypermethylation of the sirtuin 1(SIRT1) gene and demethylation of the b-amyloid pr......
Peptidyl arginine deiminase 4 participates in the pathogenesis of rheumatoid arthritis by influencin
Objective To explore the probable function of peptidyl arginine deiminase 4 (PAD4) in rheumatoid arthritis (RA) .Methods......
组蛋白去乙酰化酶抑制剂(histone deceatylase inhibitor,HDACi)是一类抑制组蛋白去乙酰化的有机化合物,通过改变组蛋白乙酰化程度......
Histone deacetylases(HDACs)play an important role in tumorigenesis.Inhibition of HDACs is considered as a potent strateg......
AIM:To investigate the effect of histone acetylation onregulation of p21~(WAF1) gene expression in human colon cancerce......
Aim:To investigate curcumin(diferuloylmethane)induced apoptosis and its mo-lecular mechanism of action in B-NHL cell li......
The secondary laticifer differentiation in rubber tree is induced by trichostatin A, an inhibitor of
The secondary laticifer, a specific tissue in the secondary phloem of rubber tree, is differentiated from the vascular c......
Spinal cord injury that results in severe neurological disability is often incurable. The poor clinical outcome of spina......
目的建立一种简单、快速、准确地检测人群外周血白细胞中泛素化组蛋白H2B （ubiquityl-histone H2B, ubH2B）修饰水平的方法。方法利用......
目的探索高氟暴露是否会影响外周血组蛋白乙酰化水平，氟骨症患者的组蛋白乙酰化水平是否存在异常，尝试从转录修饰水平上研究氟骨症的......
目的观察砷暴露人群外周血白细胞组蛋白H2AK119泛素化（H2AK119 ubiquitination，H2AK119ub）和H2BK120泛素化（H2BK120ub）修饰水平，分析砷暴......
近年来，地方性砷中毒对免疫系统的影响逐渐引起人们的关注。组蛋白修饰模式的改变可能是砷调控基因表达的机制之一，砷在调节免疫细胞......
根据美国SCI 1973～1988年间的数据,归纳出在此15年间被最多引用,亦即最有影响的 50篇苏联论文,其中生命科学研究占15篇,主要涉及蛋......
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Protein phosphatases and chromatin modifying complexes in the inflammatory cascade in acute pancreat
Acute pancreatitis is an inflammation of the pancreas that may lead to systemic inflammatory response syndrome and death......
AIM: To investigate the effects of butyrate on interleukin (IL)-32α expression in epithelial cell lines. METHODS: The h......
Alcoholism is a major health problem in the United States and worldwide,and alcohol remains the single most significant ......
Protein kinase C with a molecular weight of 82 kD has been purified to electrophoresis homogenous from rat brain through......
HDACs and HATs are two kinds of enzymes which catalyse deacetylation and acetylation of histone in eukaryotes, whose dyn......
HDACs and HATs are two kinds of enzymes which catalyse deacetylation and acetylation of histone in eukaryotes, whose dyn......
Parkinsons disease(PD) is a common,progressive neurodegenerative disease characterised by degeneration of nigrostriatal ......
AIM To investigate the potential effect of curcumin on hepatitis B virus(HBV) covalently closed circular DNA(ccc DNA) an......
