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目的观察苯扎氯铵溶液对烧伤创面的抑菌作用及对创面愈合的影响。方法 2007年10月-2008年8月共观察30名成年住院烧伤患者,按自身对照分别使用苯扎氯铵和碘伏溶液换药,在第1、第7天换药前行细菌培养观察长期抑菌作用;10例在消毒后3 min再次行细菌培养,观察其即时消毒效果;第7天观察创面愈合率。结果苯扎氯铵组和碘伏组的长期、即时抑菌作用基本类似,用药第7天创面愈合率苯扎氯铵组高于碘伏组,差异有统计学意义。两组在换药时患者感觉均有疼痛感,未见伤口周围皮肤瘙痒和皮疹。结论苯扎氯铵溶液用于烧伤创面的抑菌作用与碘伏类似,但是苯扎氯铵溶液是阳离子表面活性剂,可清洁创面血污及有机物,有利于创面愈合,有可能替代碘伏成为烧伤创面基本用药。
Objective To observe the bacteriostasis of benzalkonium chloride solution on burn wounds and its effect on wound healing. Methods From October 2007 to August 2008, 30 adult patients with in-hospital burn were observed. The patients were treated with benzalkonium chloride and iodophor respectively for dressing change. Bacterial culture was performed on the first and the seventh days before long-term Bacteriostasis was observed in 10 cases. Bacterial culture was again performed in 10 cases 3 min after disinfection. The instant disinfection effect was observed. On the 7th day, wound healing rate was observed. Results The long-term and immediate antibacterial activities of benzalkonium chloride group and iodophor group were similar. The wound healing rate of benzalkonium chloride group was higher than that of iodophor group on the 7th day. The difference was statistically significant. Patients in the two groups in the dressing when the feeling of pain, no skin pruritus and rash around the wound. Conclusions Benzalkonium chloride solution is similar to iodophor in bacteriostasis for burn wounds. However, benzalkonium chloride solution is a cationic surfactant that can clean the wound blood and organic matter, which is good for wound healing and may replace burn iodine Wound basic medication.