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目的了解北京市西城区(南)片2008-2013年疑似克雅氏病(CJD)网报病例发病情况及流行病学和临床特征,为制定该病的防治措施提供依据。方法按照《全国克雅氏病监测方案》,对经我国CJD监测网络上报的可疑病例进行临床及流行病学资料分析,收集患者脑脊液及血液样品送国家疾病预防控制中心(CDC)进行Pr P蛋白及14-3-3蛋白检测。结果 2008—2013年,北京市西城区CDC(南)共对116例疑似CJD网报病例(平均年龄54岁,男女性别比77∶39)进行流调及随访。其中,散发型CJD确诊病例1例(女,71岁);临床诊断病例5例,平均年龄67岁,男女性别比为4∶1;疑似病例18例,平均年龄为61岁,男女性别比为10∶8,致死性家族型失眠征(FFI)病例1例(女,46岁)。结论 2008—2013年北京市西城区(南)监测到的CJD疑似病例较多,临床诊断及确诊病例较少。临床及确诊病例中以散发型CJD为主,男性发病多于女性。在该病防范过程中疾病监测人员要加大宣传力度,做好病例随访和质量控制等工作。
Objective To understand the incidence, epidemiological and clinical features of suspected CJD nets in Xicheng District of Beijing from 2008 to 2013 and provide evidence for the prevention and treatment of this disease. Methods According to the “National Creutzfeldt-Jakob Disease Surveillance Program”, clinical and epidemiological data of suspected cases reported by CJD monitoring network in China were collected. Cerebrospinal fluid and blood samples of patients were collected and sent to the National Center for Disease Control and Prevention (CDC) for Pr P protein And 14-3-3 protein detection. Results From 2008 to 2013, a total of 116 suspected CJD cases (mean age 54 years, male to female ratio 77:39) were screened and followed up by CDC (South) in Xicheng District of Beijing. Among them, one case of sporadic CJD confirmed cases (female, 71 years); 5 cases of clinical diagnosis, the average age of 67 years old, male to female ratio was 4:1; 18 cases of suspected cases, the average age was 61 years old, male to female sex ratio 10:8, 1 fatal familial insomnia (FFI) cases (female, 46 years old). Conclusions There are more suspected cases of CJD in Xicheng District (South) of Beijing from 2008 to 2013, with fewer cases of clinical diagnosis and confirmed diagnosis. Clinical and confirmed cases of sporadic CJD-based, men more than women. In the course of disease prevention, disease surveillance personnel should step up publicity and do a good job in case follow-up and quality control.