论文部分内容阅读
目的:探讨 EA-10,P_5 治疗慢性前列腺炎及其合并不育症的药物机理.方法:采用生物化学法测定MDA、SOD及NO,原子吸收分光光度法测定Zn~(2+)浓度.结果:慢性前列腺炎组治疗前较对照组MDA、NO明显升高,SOD、Zn~(2+)浓度显著降低;治疗后MDA、NO明显降低,Zn~(2+)浓度显著升高,但SOD无显著性变化(P>0.05).而慢性前列腺炎合并不育症组治疗前较对照组MDA、NO明显升高,SOD、Zn~(2+)浓度显著降低;治疗后MDA、NO明显降低,SOD、Zn~(2+)浓度显著升高,同时精子的活动率、死亡率较治疗前明显好转.结论:氧自由基与慢性前列腺炎的发生发展及好转有着密切关系;EA-10,P_5用于治疗慢性前列腺炎及其合并不育症的药物机理与氧自由基的改变有关.
OBJECTIVE: To explore the drug mechanism of EA-10 and P_5 in the treatment of chronic prostatitis and its combined infertility.Methods: The contents of MDA, SOD and NO were determined by biochemical method, and the concentration of Zn2 + was determined by atomic absorption spectrophotometry : Compared with the control group, the levels of MDA and NO in chronic prostatitis group were significantly increased and the concentrations of SOD and Zn ~ (2+) were significantly decreased. After treatment, the levels of MDA and NO were significantly decreased while the concentrations of Zn2 + (P> 0.05), but the levels of MDA and NO in the chronic infertility group were significantly higher than those in the control group before treatment, the concentrations of SOD and Zn2 + were significantly decreased; the levels of MDA and NO were significantly decreased after treatment , The concentration of SOD and Zn ~ (2+) increased significantly, while the activity and mortality of sperm were significantly improved than before treatment.Conclusion: Oxygen free radicals are closely related to the occurrence, development and improvement of chronic prostatitis. EA-10, P_5 for the treatment of chronic prostatitis and its mechanism of combined infertility and oxygen free radicals related to changes in the mechanism.