This report presents a design system based on the use of CsI(TI) detectors to search for lost radioactive sources that are dangerous and harmful to individuals, including searching persons. For this purpose, the GEANT4 simulation toolkit was utilized to develop a system based on three detectors. Various simulated anal-yses were performed on the dose rates of the three detectors using different source–detector distances and detector separation. There were good agreement between the sim-ulated results and the experimentally measured data. A new method was discussed to detect and search for radioactive sources based only on the dose rates in detectors with source activity. Numerical analyses were performed based on the measured dose rates and the difference of distances to determine the actual location of the lost single or mul-tiple γ-ray sources at a specific angle. The detection limit was calculated from the background radiation to establish the sensitivity and capability of the proposed detector system. This system can be applied in fields in which it is necessary to locate unknown radioactive sources.