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目的 :观察中药制剂抗震止痉胶囊合谷胱甘肽治疗帕金森病 (PD)的临床疗效及其对患者血抗氧化酶的影响。方法 :将西医常规治疗疗效明显衰减的PD病人 88例随机分为中药组 ( 30例 )、中药加谷胱甘肽组 ( 2 9例 )及西医常规治疗组 ( 2 9例 ) ,分别给予相应的治疗 ,另设正常对照组2 0例 ,观察其疗效 ,并检测各组用药前后的血抗氧化酶活性。结果 :①显效率比较 :中药组 56.7% ,中药加谷胱甘肽组为 75.8% ,西医常规治疗组为 4 4 .8%。中药加谷胱甘肽组与中药组及西医常规治疗组比较 ,其显效率均有显著差异 (P <0 .0 5,P <0 .0 1)。②Webster评分比较 :中药组和中药加谷胱甘肽组治疗前后Webster评分比较均有显著差异 (P <0 .0 5,P <0 .0 1)。③对血抗氧化酶的影响 :中药组、中药加谷胱甘肽组、西医常规治疗组治疗前抗氧化指标均较正常组有明显差异(P <0 .0 5,或P <0 .0 1) ,中药加谷胱甘肽和中药组对PD患者血抗氧化酶活性均有增强效应 (P<0 .0 5,P <0 .0 1) ;而西医常规治疗组血抗氧化酶活性治疗后明显下降 (P <0 .0 5)。结论 :抗震止痉胶囊合谷胱甘肽对西医常规治疗疗效明显衰减的PD患者具有较好的疗效 ,提示其对PD可能具有神经保护性治疗作用 ,而西医常规治疗在一定程度上降低了PD病人的抗氧化能力 ,提示长期?
Objective: To observe the clinical curative effect of anti-Zhenzhizhentang Capsule combined with glutathione on Parkinson’s disease (PD) and its effect on blood antioxidant enzymes. Methods: Eighty-eight patients with PD who had a significant reduction in conventional therapy were randomly divided into three groups: Chinese medicine group (30 cases), Chinese medicine plus glutathione group (29 cases) and Western medicine routine treatment group (29 cases) The other 20 cases of normal control group, observe the curative effect, and test the blood antioxidant enzyme activity of each group before and after treatment. Results: ① significant efficiency comparison: Chinese medicine group 56.7%, Chinese medicine plus glutathione group was 75.8%, conventional Western medicine group was 44.8%. Compared with traditional Chinese medicine group and western medicine group, the effective rates of Chinese medicine plus glutathione group were significantly different (P <0.05, P <0.01). ②Webster score comparison: Chinese medicine group and Chinese medicine plus glutathione group Webster score before and after treatment were significantly different (P <0.05, P <0.01). (3) The impact of blood antioxidant enzymes: Chinese medicine group, traditional Chinese medicine plus glutathione group, western medicine conventional treatment group before treatment, antioxidant index were significantly different from the normal group (P <0. 05, or P <0 .0 1), Chinese medicine plus glutathione and traditional Chinese medicine group had an enhanced effect on blood antioxidant enzyme activity in PD patients (P <0.05, P <0.01), while the Western medicine routine treatment group, blood antioxidant enzyme activity After treatment decreased significantly (P <0. 05). Conclusion: The anti-Seizhezhijing capsule combined with glutathione has a good curative effect on PD patients with obvious curative effect of western medicine treatment, suggesting that it may have neuroprotective effect on PD, while conventional western medicine can reduce PD patients to a certain extent Antioxidant capacity, suggesting long-term?